Biosensing and molecular diagnosis have a market size of USD 29 billion (2023) and are considered an area with enormous growth and commercial potential (CAGR 8%). This multidisciplinary field requires inputs from chemists, biologists, clinicians, physicists, electronics, and mechanical engineers. Dr Ghosh closely works with several collaborators from these fields and tries to build novel assays to enable and develop biosensing devices with biomedical, agricultural, and environmental applications.
S Tripathy, T Agarkar, A Talukdar, M Sengupta, A Kumar*, S Ghosh**. Evaluation of indirect sequence-specific magneto-extraction-aided LAMP for fluorescence and electrochemical SARS-CoV-2 nucleic acid detection. Talanta. 2023, 252, 123809.
T Agarkar, VK Nair, S Tripathy, V Chawla, S Ghosh, A Kumar.* Oxygen Vacancy Modulated MnO2 Bi-Electrode System for Attomole-Level Pathogen Nucleic Acid Sequence Detection, Electrochim Acta, 2022, 407, 139876.
S Tripathy, A Talukdar, PV Rajesh, G Pramanik*, S Ghosh*. Limited-Resource Preparable Chitosan Magnetic Particles for Extracting Amplification-Ready Nucleic Acid from Complex Biofluid. Analyst, 2022, 147, 165.
T Agarkar, S Tripathy, V Chawla, M Sengupta, S Ghosh*, A Kumar**. A batch processed titanium-vanadium oxide nanocomposite based solid-state electrochemical sensor for zeptomolar nucleic acid detection. Analytical Methods, 2022, 14, 4495.
S Kumar, A Kharb, A Vazirani, RS Chauhan, G Pramanik, M Sengupta, S Ghosh*. Nucleic acid extraction from complex biofluid using toothpick-actuated over-the-counter medical-grade cotton. Bioorg Med Chem. 2022, 73, 117009.
VK Nair, C Sharma, M Sengupta, S Ghosh*. Mitigating the Non-Specific Amplification in RCA: Assessment of the Role of Ligation and Exonuclease Digestion in Circular DNA Preparation. [in Revision]
Long MJC, Poganik JR, Ghosh S, Aye Y. Subcellular Redox Targeting: Bridging In Vitro And In Vivo Chemical Biology. ACS Chem Biol. 2017, 12, 586-600.
Xu W, Ouellette A, Ghosh S, O'Neill TC, Greenberg MM, Zhao L. Mutagenic Bypass Of An Oxidized Abasic Lesion-Induced DNA Interstrand Cross-Link Analogue By Human Translesion Synthesis DNA Polymerases. Biochemistry. 2015, 54, 7409-7422.
Xu W, Ghosh S, Ouellette A, Greenberg MM, Zhao L. Replication dependent DNA repair of DNA interstrand cross-links by human translesion DNA polymerases. Abstracts of Papers of the American Chemical Society. Volume 250 (conference presentation)
Ghosh, S.; Greenberg, M. M., Correlation of Thermal Stability and Structural Distortion of DNA Interstrand Cross-Links Produced from Oxidized Abasic Sites with Their Selective Formation and Repair. Biochemistry. 2015, 54, 6274-6283.
Ghosh, S., Greenberg, M. M., Nucleotide Excision Repair Of Chemically Stabilized Analogues Of DNA Interstrand Cross-Links Produced From Oxidized Abasic Sites. Biochemistry 2014, 53, 5958-5965.
Ghosh, S., Greenberg, M. M., Synthesis of Cross-Linked DNA Containing Oxidized Abasic Site Analogues. J. Org. Chem. 2014, 79, 5948 - 5957. [**Featured article]
George, C., Ghosh, S., Chandrakumar, N., 29Si NMR-Transition Selective Double Quantum Filter Experiments In One And Two Dimensions. Future Directions in NMR; Editors: Khetrapal, C. L.; Kumar, A.; Ramanathan, K. V.; Springer, 2014, pp 231-237. (ISBN 978-81-8489-995-5)
Dr. Ghosh’s research lab currently focuses on the following areas;
Instrument and method development to enable field-based near-point-of-care detection of pathogens
Assay development for elucidating molecular DNA damage pathways
Method development to better understand host-pathogen interaction at the molecular level
Research Area of Interest
Cancer Biology Area 1: Early cancer detection and understanding the effect of radiotherapy
Cancer Biology Area 2: Cancer therapeutics and augmenting radio-therapeutics using supplements
Method and instrument development for biomarker detection
We work at the interface of medicine, biomaterials, and biochemistry. Along with conventional training, strong emphasis is put at collaborations, personalized mentoring, science communication, and industrial training. Following are encouraged to approach.
JRFs from DST INSPIRE
JRFs from ICMR / UGC / DBT / CSIR
RAs with postdoc fellowships like NPDF, ICMR, DBT RA etc.