Souradyuti Ghosh

Biosensing and molecular diagnosis have a market size of USD 29 billion (2023) and are considered an area with enormous growth and commercial potential (CAGR 8%). This multidisciplinary field requires inputs from chemists, biologists, clinicians, physicists, electronics, and mechanical engineers. Dr Ghosh closely works with several collaborators from these fields and tries to build novel assays to enable and develop biosensing devices with biomedical, agricultural, and environmental applications.

• Ph.D. from Johns Hopkins University, Baltimore, USA: (2009 – 2015)
• M.Sc. from Indian Institute of Technology Madras, Chennai, India: (2006 – 2008)
• B.Sc. from Ramakrishna Mission Residential College Narendrapur (University of Calcutta), Kolkata, West Bengal, India: (2003 – 2006)

• S Parveen, A Talukdar, M Sengupta, S Ghosh*. Evaluating horseradish peroxidase-mimic DNAzyme transducer for glucometer readout: roles of various components and their optimization. BioRxiv 2025 (DOI: 10.1101/2025.06.27.661989)
• PN Gaikwad, TR Desai, S Ghosh, C Gurnani. Flexible Nanostructured NiS-Based Electrochemical Biosensor for Simultaneous Detection of DNA Nucleobases, ACS Omega, 2024. (DOI: 10.1021/acsomega.4c07106)
• VK Nair, C Sharma, S Kumar, M Sengupta, S Ghosh*. Mitigating the Non-Specific Amplification in RCA: Assessment of the Role of Ligation and Exonuclease Digestion in Circular DNA Preparation. RSC Analyst, 2024, DOI: 10.1039/D4AN00866A (Preprint ChemRxiv https://doi.org/10.26434/chemrxiv.14577975.v1)
• S Kumar, HS Gariya, C Sharma, S Parveen, VK Nair, M Sengupta, S Ghosh*. An anomalous 3’-terminal phosphorothioated mismatch bypass activity and its application as a binary molecular switch. BioRxiv preprint 2024. (DOI: https://doi.org/10.1101/2024.07.27.605420)
• S Tripathy#, T Agarkar#, A Talukdar, M Sengupta, A Kumar, S Ghosh*. Comparative Evaluation of Indirect Sequence-Specific Magnetoextraction-aided Fluorescence and Electrochemical LAMP with SARS-CoV-2 Nucleic Acid as the Analyte. Talanta. 2023, 252,123809. [# joint 1st author] [DOI: 10.1016/j.talanta.2022.123809]
• T Agarkar#, S Tripathy#, V Chawla, M Sengupta, S Ghosh, A Kumar*. A batch processed titanium–vanadium oxide nanocomposite based solid-state electrochemical sensor for zeptomolar nucleic acid detection. RSC Anal. Methods, 2022,14, 4495-4513. [# joint 1st author] [selected as Analytical Methods HOT Articles 2022]
• S Kumar, A Kharb, A Vazirani, RS Chauhan, G Pramanik, M Sengupta, S Ghosh*, Nucleic acid extraction from complex biofluid using toothpick-actuated over-the-counter medical-grade cotton. Bioorganic and Medicinal Chem, 2022, 73,117009.
• T Agarkar#, VK Nair#, S Tripathy, V Chawla, S Ghosh, A Kumar.* Oxygen Vacancy Modulated MnO2 Bi-Electrode System for Attomole-Level Pathogen Nucleic Acid Sequence Detection, Electrochimica Acta, 2022, 407, 139876, : [DOI: https://doi.org/10.1016/j.electacta.2022.139876]. [# joint 1st author]
• S Tripathy, A Talukdar, PV Rajesh, G Pramanik, S Ghosh. Limited-Resource Preparable Chitosan Magnetic Particles for Extracting Amplification-Ready Nucleic Acid from Complex Biofluid. RSC Analyst, 2022,147, 165-177.
• Long MJ,* Ghosh S,* Haegele JA, Aye Y. G-REX: global T-REX in worms to detect electrophilic signalling proteins [manuscript in preparation][* joint 1st author]
• Long MJ, Poganik JR, Ghosh S, Aye Y.. Subcellular Redox Targeting: Bridging In Vitro and In Vivo Chemical Biology. ACS Chem Biol. [DOI: 10.1021/acschembio.6b01148.] [Impact Factor 4.6]
• Ghosh, S.; Greenberg, M. M., Synthesis of cross-linked DNA containing oxidized abasic site analogues. J. Org. Chem. 2014, 79, 5948. [**Featured article] [Impact Factor 4.2]
• Ghosh, S.; Greenberg, M. M., Nucleotide excision repair of chemically stabilized analogues of DNA interstrand cross-links produced from oxidized abasic sites. Biochemistry 2014, 53, 5958. [Impact Factor 3.3]
• Ghosh, S.; Greenberg, M. M., Correlation of Thermal Stability and Structural Distortion of DNA Interstrand Cross-Links Produced from Oxidized Abasic Sites with Their Selective Formation and Repair. Biochemistry. 2015, 54, 6274. [Impact Factor 3.3]
• Xu W, Ouellette A, Ghosh S, O’Neill TC, Greenberg MM, Zhao L. Mutagenic Bypass of an Oxidized Abasic Lesion-Induced DNA Interstrand Cross-Link Analogue by Human Translesion Synthesis DNA Polymerases. Biochemistry. 2015, 54, 7409. [Impact Factor 3.3]
• George, C.; Ghosh, S.; Chandrakumar, N., 29Si NMR-Transition Selective Double Quantum Filter Experiments in One and Two Dimensions. Future Directions in NMR; Editors: Khetrapal, C. L.; Kumar, A.; Ramanathan, K. V.; Springer, 2014, pp 231-237. (ISBN 978-81-8489-995-5).

Dr. Ghosh’s research lab currently focuses on the following areas;Instrument and method development to enable field-based near-point-of-care detection of pathogens

1. Assay development for elucidating molecular DNA damage pathways
2. Method development to better understand host-pathogen interaction at the molecular level
3. Live biosensors

Research Area of Interest

1. Cancer Biology Area 1: Early cancer detection and understanding the effect of radiotherapy
2. Cancer Biology Area 2: Cancer therapeutics and augmenting radio-therapeutics using supplements
3. Method and instrument development for biomarker detection

Openings

We work at the interface of medicine, biomaterials, and biochemistry. Along with conventional training, strong emphasis is put at collaborations, personalized mentoring, science communication, and industrial training. Following are encouraged to approach.

• JRFs from DST INSPIRE
• JRFs from ICMR / UGC / DBT / CSIR
• RAs with postdoc fellowships like NPDF, ICMR, DBT RA etc.
• 6 months MSc student thesis projects

For more details on our Science, please see our papers or write to us at souradyutighoshacademic@gmail.com
You can also visit the lab by contacting us in advance.

FUNDING

• The projects are kindly supported by
  • DBT SARS-CoV-2 Detection grant (2020 – 2022)
  • DST INSPIRE PhD fellowship 2023 for Ms Saba Parveen
  • DST Early career grant (2019-22)
  • DST Nanomission Nanobio category (2019-22)