Thakur Santosh is an Assistant Professor in the Centre for Life Sciences at Mahindra University. He earned the Doctor of Philosophy in Knowledge Capturing and Analysis of Big Data from Department of Computer Science and Engineering, Indian Institute of Technology (Indian School of Mines), Dhanbad. He has nine years of experience in teaching and research.

• Ph.D. from Indian Institute of Technology (Indian school of Mines), Dhanbad in 2021.
• M.Tech. (CSE) from Jawaharlal Nehru Technological University -Hyderabad -in 2012.

Journals :

• Voisin, E., Thakur, S., Nayak, J., Chakrabortty, S., & Pal, P. (2024). Application of Neural Network in Prediction of acetic acid yield by Acetobacters. South African Journal of Chemical Engineering.
• Thakur, S., Dharavath, R., Shankar, A., Singh, P., Diwakar, M., & Khosravi, M. R. (2022). RST-DE: Rough Sets-Based New Differential Evolution Algorithm for Scalable Big Data Feature Selection in Distributed Computing Platforms. Big Data.

• Thakur, S., Dharavath, R., & Edla, D. R. (2020). Spark and Rule-KNN based scalable machine learning framework for EEG deceit identification. Biomedical Signal Processing and Control, 58, 101886.
• Santosh, T., Ramesh, D., & Reddy, D. (2020). LSTM based prediction of malaria abundances using big data. Computers in Biology and Medicine, 124, 103859.
• Santosh, T., & Ramesh, D (2020). Machine Learning Approach on Apache Spark for Credit Card Fraud Detection Machine Learning Approach on Apache Spark for Credit Card Fraud Detection.

• Thakur, S., & Dharavath, R. (2019). Artificial neural network-based prediction of malaria abundances using big data: A knowledge capturing approach. Clinical Epidemiology and Global Health, 7(1), 121-126.

Conferences :

• Ramesh, D., Santosh, T., Trivedi, M. C., & Le, C. H. (2025). Ensuring digital sovereignty in cross-chain EHR sharing: a relay-as-a-service approach for secure healthcare interoperability. Procedia Computer Science, 254, 48-57.
• Kolla, S. S., Ramesh, D., Santosh, T., & Narvaneni, R. (2024, June). Hybrid Grey Wolf Algorithmic Approach for Optimizing Workflow Scheduling with Budget and Deadline Constraints in IaaS Clouds. In 2024 15th International Conference on Computing Communication and Networking Technologies (ICCCNT) (pp. 1-10). IEEE.
• Santosh, T., & Ramesh, D. (2019, May). DENCLUE-DE: Differential Evolution Based DENCLUE for Scalable Clustering in Big Data Analysis. In International Conference on Computer Networks and Inventive Communication Technologies (pp. 436-445). Springer, Cham.

• Thakur, S., & Dharavath, R. (2018). KMDT: A Hybrid Cluster Approach for Anomaly Detection Using Big Data. In Information and Decision Sciences(pp. 169-176). Springer, Singapore.

• Santosh, T., & Ramesh, D. (2017, October). Spark Based ANFIS Approach for Anomaly Detection Using Big Data. In International Conference on Next Generation Computing Technologies(pp. 450-458). Springer, Singapore.

Google Scholar Profile: https://scholar.google.com/citations?user=PT_-YmoAAAAJ&hl=en

• 2022- Present Assistant Professor Center for Life Sciences Mahindra University.
• Assistant Professor in Woxsen University, Hyderabad from June-2021 to July-2022.
• Assistant Professor in DIT University, Dehradun from Jan- 2013 to Feb-2021.

Current research interests in the areas of Data Science, Machine learning and Blockchain.

Varun Kumar received his Ph.D. in Biotechnology from the Jaypee University of Information Technology, Himachal Pradesh. His doctorate research was carried out in a Programme support under ‘Centres of Excellence’ scheme of DBT, Gov. of India. Dr. Kumar’s research contributed to the elucidation of novel metabolic pathways for the biosynthesis of major phytochemicals in endangered Himalayan medicinal herbs. He is a recipient of ‘ARO postdoctoral fellowship’ of the Volcani Center, Israel, and the ‘Maria Zambrano postdoctoral fellowship’ of UPM, Spain. His postdoc research at ARO led to improved plants’ response to necrotrophic and insects’ pathogens. Dr. Kumar’s research revealed the mechanisms behind induced resistance in a variety of plant species including; chrysanthemum flowers and leaves of petunia, tomato and Arabidopsis. During his postdoc at CBGP, Spain, he investigated novel mechanisms of perception of plant cell-wall derived oligosaccharides and immune activation in Arabidopsis thaliana. His current lab interests are focused on engineering suitable hosts for production of high-value industrial phytochemicals, and the developing eco-friendly pest control strategies for controlling crop diseases.

• Ph.D. Biotechnology (2012-2017), Jaypee University of Information Technology, Solan, H.P., India
• M.Sc. Biotechnology (2008-2010), Kurukshetra University, Kurukshetra, Haryana, India
• B.Sc. Botany, Zoology, Chemistry (2005-2008), Kurukshetra University, Kurukshetra, Haryana, India.

• Wang R, Kumar V, Sikron-Persi N, Dynkin I, Weiss D, Perl A, Fait A and Oren-Shamir M (2022). Over a thousand-fold synergistic boost in viniferin levels by elicitation of Vitis vinifera cv. Gamay Red cell cultures over-accumulating phenylalanine. J. Agric. Food Chem. 70: 5049-5056.

• Kumar V, Elazari Y, Ovadia, R, Bar E, Nissim-Levi A, Carmi N, Lewinsohn E and Oren-Shamir M (2021). Phenylalanine treatment generates scent in flowers by increased production of phenylpropanoid-benzenoid volatiles. Postharvest Biol. Technol. 181: 111657.
• Wang R, Lenka SK, Kumar V, Sikron-Persi N, Dynkin I, Weiss D, Perl A, Fait A and Oren-Shamir M (2021). A synchronized increase of stilbenes and flavonoids in metabolically engineered Vitis vinifera cv. Gamay Red cell culture. J. Agric. Food Chem. 69: 7922-7931.
• Wang R, Lenka SK, Kumar V, Gashu K, Sikron-Persi N, Dynkin I, Weiss D, Perl A, Fait A and Oren-Shamir M (2021). Metabolic engineering strategy enables a hundred-fold increase in viniferin levels in Vitis vinifera cv. Gamay red cell culture. J. Agric. Food Chem. 69: 3124-3133.
• Fang F, Oliva M, Ovadia R, Bar E, Nissim-Levi A, Kumar V, Wang R, Neeman A, Zaccai M, Lewinsohn E and Oren-Shamir M (2021). Increased substrate availability reveals the potential of scentless lisianthus flowers in producing fragrant benzenoid-phenylpropanoids. Physiol. Plant. 172: 19-28.
• Kumari A, Kumar V and Malhotra N (2021). Stevia rebaudiana. In: Malhotra N and Singh M (Eds.), Himalayan Medicinal Plants. Academic press, pp. 199-221.

• Kumar V, Hatan E, Bar E, Davidovich-Rikanati R, Doron-Faigenboim A, Elad Y, Alkan N, Lewinsohn E, Spitzer-Rimon B and Oren-Shamir M (2020). Phenylalanine increases Chrysanthemum flower immunity against Botrytis cinerea attack. Plant J. 104: 226-240.
• Oliva M, Hatan E, Kumar V, Galsurker O, Nisim-Levi A, Ovadia R, Galili G, Lewinsohn E, Elad Y, Alkan N and Oren-Shamir M (2020). Increased phenylalanine levels in plant leaves reduces susceptibility to Botrytis cinerea. Plant. Sci. 290:110289.

• Kumar A, Kumar V, Krishnan V, Hada A, Marathe A, Parameswaran C, Jolly M and Sachdev A (2019). Seed targeted RNAi-mediated silencing of GmMIPS1 limits phytate accumulation and improves mineral bioavailability in soybean. Sci. Rep. 9:7744.
• Kumar V (2019). OMICS-based approaches for elucidation of picrosides biosynthesis in Picrorhiza kurroa. In: Banerjee R, Kumar GV and Kumar SPJ (Eds.), OMICS-Based Approaches in Plant Biotechnology. Scrivener Publishing, pp. 145–166.

• Kumar A, Kumar V, Krishnan V, Hada A, Marathe A, Parameswaran C, Jolly M and Sachdev A (2019). Seed targeted RNAi-mediated silencing of GmMIPS1 limits phytate accumulation and improves mineral bioavailability in soybean. Sci. Rep. 9:7744.
• Kumar V (2019). OMICS-based approaches for elucidation of picrosides biosynthesis in Picrorhiza kurroa. In: Banerjee R, Kumar GV and Kumar SPJ (Eds.), OMICS-Based Approaches in Plant Biotechnology. Scrivener Publishing, pp. 145–166.

• Kumar V, Sharma N, Sood H and Chauhan RS (2016). Exogenous feeding of immediate precursors reveals synergistic effect on picroside-I biosynthesis in shoot cultures of Picrorhiza kurroa Royle ex Benth. Sci. Rep. 6:29750.
• Kumar V, Malhotra N, Pal T and Chauhan RS (2016). Molecular dissection of pathway components unravel atisine biosynthesis in a non-toxic Aconitum species, A. heterophyllum Wall. 3 Biotech 6(1):1-10.
• Sharma N, Kumar V, Chauhan RS and Sood H (2016). Modulation of Picroside-I Biosynthesis in Grown Elicited Shoots of Picrorhiza kurroa In Vitro. J. Plant Growth Regul. 35(4):965-973.
• Kumar V and Chauhan RS (2016). Higher amount of steviol detected in the leaves of a non-toxic endangered medicinal herb, Aconitum heterophyllum. J. Plant Biochem. Biotechnol. 25(4):442-445.
• Kumar V, Shitiz K, Chauhan RS, Sood H and Tandon C (2016). Tracking dynamics of enzyme activities and their gene expression in Picrorhiza kurroa with respect to picroside accumulation. J. Plant Biochem. Biotechnol. 25(2):125-132.
• Kumar P, Kumar V and Kumar GV (2016). Biosynthesis and pharmacological evaluation of shikonin-A highly valuable metabolite of North-Western Himalayas: Mini Review. Medicinal Plants – International Journal of Phytomedicines and Related Industries 8(4):267-274.

• Kumar V, Sharma N, Shitiz K, Singh TR, Tandon C, Sood H and Chauhan RS (2015). An insight into conflux of metabolic traffic leading to picroside-I biosynthesis by tracking molecular time course changes in a medicinal herb, Picrorhiza kurroa. Plant Cell Tiss. Org. Cult. 123(2):435-441.
• Kumar V, Singh TR, Hada A, Jolly M, Ganapathi A and Sachdev A (2015). Probing Phosphorus Efficient Low Phytic Acid Content Soybean Genotypes with Phosphorus Starvation in Hydroponics Growth System. Appl. Biochem. Biotechnol. 177(3):689-99.
• Kumar V, Kumar V, Chauhan RS, Sood H and Tandon C (2015). Cost effective quantification of picrosides in Picrorhiza kurroa by employing response surface methodology using HPLC-UV. J. Plant Biochem. Biotechnol. 24(4):376-384.
• Kumar A, Kumar V, Lal SK, Jolly M and Sachdev A (2015). Influence of gamma rays and ethyl methane sulphonate (EMS) on the levels of phytic acid, raffinose family oligosaccharides and antioxidants in soybean seeds of different genotypes. J. Plant Biochem. Biotechnol. 24:204-209.

• Kumar V, Kayasth M, Chaudhary V and Gera R (2014). Diversity of diazotrophs in arid and semi-arid regions of Haryana and evaluation of their plant growth promoting potential on Bt-cotton and pearl millet. Ann. Microbiol. 64(3):1301-1313.
• Kumar V and Gera R (2014). Isolation of a multi-trait plant growth promoting Brevundimonas sp. and its effect on the growth of Bt-cotton. 3 Biotech 4(1):97-101.
• Gera R, Kumar V and Shekhawat K (2014). Genotypic diversity of native population of rhizobia nodulating Vicia faba plants in arid and semi-arid regions of Haryana (India). Ann. Microbiol. 64(2):619-626.
• Kayasth M, Gera R, Dudeja SS, Sharma PK and Kumar V (2014). Studies on salinization in Haryana soils on free-living nitrogen-fixing bacterial populations and their activity. J. Basic Microbiol. 54(3):170-179.
• Kayasth M, Kumar V and Gera R (2014). Gordonia sp.: a salt tolerant bacterial inoculant for growth promotion of pearl millet under saline soil conditions. 3 Biotech 4(5):553-557.
• Gera R, Kumar V, Kayasth M, Walia M, Singh S and Goyal S (2014). Exploring the potential of phosphate solubilising diazotrophic Pseudomonas sp Db76 as plant growth promoter for Bt cotton. Journal of Cotton Research and Development 28(2):311-315.
• Gera R, Bhatia R, Kumar V, Kayasth M, Walia M, Kaur H and Goyal S (2014). Diversity and antibacterial activity of actinobacteria isolated from cotton fields in semi-arid zones of Haryana. Journal of Cotton Research and Development 28(1):129-134.

• Kayasth M, Kumar V and Gera R (2013). Exploring the potential of PGPR strain Bacillus licheniformis to be developed as multifunctional Biofertilizer. Central European Journal of Experimental Biology 2(1):12-17.

• Kuhar K, Kumar V, Kansal R and Gupta VK (2012). Isolation and in silico characterization of cDNA encoding cyclophilin from etiolated Vigna mungo seedlings. Braz. J. Plant Physiol. 24(1):69-73.
• Gera R, Bhatia R and Kumar V (2012). Comparison of nodC and 16S rDNA gene analysis of rhizobia associated with legumes of arid and semi-arid regions of Haryana. Journal of Food Legumes 25(4):294-299.
• Kayasth M, Kumar V and Gera R (2012). Isolation and identification of diazotrophic Bacillus subtilis strain SS2 from saline soil and its potential to be used as Biofertilizer. J. Microbiol. Biotech. Res. 2(5):772-777.

• 2022- Present Assistant Professor Center for Life Sciences Mahindra University.
• Maria Zambrano Postdoctoral Fellow (2022), Center for Plant Biotechnology and Genomics, Madrid, Spain
• Postdoctoral Fellow (2018-2022), Agricultural Research Organization, The Volcani Center, Israel
• Senior Research Fellow-DBT COE Phase-II (2017), Jaypee University of Information Technology, Solan, H.P., India
• Senior Research Fellow-DBT COE Phase-I (2012-2015), Jaypee University of Information Technology, Solan, H.P., India
• Senior Research Fellow-ICAR (2011-2012), Division of Biochemistry, Indian Agricultural Research Institute, New Delhi, India
• Senior Research Fellow-ICAR (2010-2011), Department of Microbiology, CCS Haryana Agricultural University, Hisar, India

Our lab goal is intended to make innovative changes for development of ‘Superior’ and ‘Stronger’ plants.

1. Engineering suitable hosts for production of high-value industrial phytochemicals
   
   Plants are a rich source for specialized metabolites serving in healthcare, nutritional and cosmetic industries. The supply of these metabolites is often obstructed due to the complexity of their tissue-specific production, existence of modified structures and lack of culture platforms and/or alternate production systems. These limitations pose challenges for industries in acquiring quality raw material with adequate amount of the target phytochemical. Our goal is to establish sustainable and superior production platform systems for specific phytochemicals of interest, by (a) Elucidation of biosynthetic routes for the production of target phytochemicals, and (b) Metabolic engineering either in the native host or in heterologous host for generation of superior systems.
   
2. Eco-friendly pest control strategy for economically important crops and ornamentals
   
   Plants suffer from pests and diseases causing losses worldwide of up to 40% of crop yields. The protection of plants from pathogens is provided mainly by use of chemical pesticides, that eventually harm the environment and the health of farmers and consumers, and often result in development of resistant pathogen strains. Our lab is interested in understanding and exploring natural plant immune mechanisms to induce resistance against crop diseases by: (a) Identifying and over-producing specialized metabolites involved in the plant defense response; (b) Understanding plant defense signaling upon pathogen attack; and (c) Identifying potential active natural molecules and the mechanisms by which they protect plants.

Akanksha Singh is an Assistant Professor in the Center for Life Sciences at the Mahindra University. She earned her PhD degree in the Department of Zoology, Banaras Hindu University. She investigated the evolutionary conservation of sexual behavioral traits, in a closely related Drosophila species using behavioral and genetic tools. Later, she moved to Cornell University and in collaboration with Syracuse University she identified the interaction between male and female reproductive proteins and their possible roles in reproduction using transgenic and omics technologies. The findings provide a deeper understanding on genetic and molecular basis of infertilities in a population and several pitfalls involved in the assisted reproductive technologies like In vitro fertilization. Then she moved to the Laboratory of Systems Genetics, National Heart Lung and Blood Institute, Bethesda where she worked to understand the genetic basis of difference in sleep duration using Polycistronic CRISPR/Cas9 gene editing technologies combined with transgenic approaches. She also undertook GWAS (Genome wide association studies) approach to identify sleep conservation in closely related Drosophila species.

• Ph.D. Zoology (2011-2015), Department of Zoology, Banaras Hindu University, Varanasi, India
• M. Sc. Zoology (2008-2010), specialization in Biochemistry and Molecular Biology, Department of Zoology, Banaras Hindu University, Varanasi, India
• B.Sc. Zoology (2006-2008), Banaras Hindu University, Varanasi, India

• Misra S, Buehner NA, Singh A, Wolfner MF 2022. Female factors are important for the seminal Sex Peptide’s association with sperm, in mated D. melanogaster. BioRxiv,
  https://doi.org/10.1101/2022.05.13.
  Under revision in BMC Biology.
• McCullough EL*, Whittington E*, Singh A*, Pitnick S, Wolfner MF, Dorus S 2022. The life history of Drosophila sperm involves molecular continuity between male and female reproductive tracts. PNAS, 119 (11): e2119899119. (*Co-first author) (Cover Page Image of the Issue)
  https://www.pnas.org/toc/pnas/119/11

Media coverage:

• Science Daily: https://www.sciencedaily.com/releases/2022/03/220308102840.htm
• Cornell Chronicle: https://news.cornell.edu/stories/2022/03/after-mating-fruit-fly-sperm-are-no-longer-fully-male
• Syracuse Univ News: https://thecollege.syr.edu/news-all/news-from-2022/as-biologists-observe-a-molecular-hand-off-that-plays-a-key-role-in-reproduction/
• Verve Times-News: https://vervetimes.com/biologists-observe-a-molecular-hand-off-that-plays-a-key-role-in-reproduction-sciencedaily/
• Phys.org News: https://phys.org/news/2022-03-biologists-molecular-hand-off-key-rol…
• News Medical Life sciences: https://www.news-medical.net/news/20220308/Research-sheds-light-on-important-events-that-may-play-a-role-in-infertility.aspx
• Singh A*, Buehner NA, Lin He, Baranowski KJ, Findlay GD, Wolfner MF 2018. Long-term interaction between Drosophila sperm and sex peptide is mediated by other seminal proteins that bind only transiently to sperm. Insect Biochemistry and Molecular Biology, 102: 43-51.
• Singh BN and Singh A 2016. The Genetics of sexual behavior of Drosophila. Advances in genomics and genetics, 6: 1-9
• Singh A* and Singh BN 2015. Sperm displacement in the Drosophila bipectinata species complex: Evidence for interspecific variations. Behavioural Processes, 113:105-109.
• Singh A* and Singh BN 2014. Studies on remating behavior in the Drosophila bipectinata species complex. Evidence for sperm displacement in D. bipectinata. Current Science, 107: 511-515.
• Singh A* and Singh BN 2014. Role of sexual selection in speciation in Drosophila. Genetica, 142: 23-41.
• Singh A* and Singh BN 2013. Mating latency, duration of copulation, and fertility in four species of D. bipectinata complex. Indian Journal of Experimental Biology, 52:175-80.
• Singh A* and Singh BN 2013. Studies on remating behavior in the Drosophila bipectinata species complex: Intra- and interspecific variations. Behavioral Processes, 96: 79-87
• Singh BN and Singh A 2014. A new mutation in Drosophila parabipectinata. Drosophila Information Services, 97:175-17
• Singh BN and Singh A 2013. A new mutation in Drosophila malerkotliana. Drosophila Information Services, 96: 221-222

• 2022- Present Assistant Professor Center for Life Sciences Mahindra University.
• Research Fellow (2021- August 2022) Laboratory of Systems Genetics, National Heart Lung and Blood Institute, Bethesda, Maryland: (2021 – 2022)
• Postdoctoral Visiting Fellow (2019-2021) Laboratory of Systems Genetics, National Heart Lung and Blood Institute, Bethesda, Maryland: (2019 – 2021)
• Postdoctoral Associate (2015-2018) Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York: (2015 – 2018)

• Our research will focus to understand the genetic basis of certain common disease affecting human population. Using genome wide association studies (GWAS) and other omics (genomics and transcriptomics) as well as genome editing technologies we would be identifying specific risk alleles present in coding or non-coding regions (regulatory regions). The impact of this study will thereby provide pipelines for functionally identifying causal regulatory SNPs (and regulatory elements) of complex diseases. This will be of enormous benefit for a confident diagnosis, establishing personalized treatment options, and also surveillance for the high-risk patients and their relatives.
• In an other study I will be working to understand the systems genetics of sleep using Drosophila melanogaster as a model system where I would like to develop the relationship between gut microbiome and immune response with sleep in Drosophila.
  
  Awards
• 2021, Fellows Award for Research Excellence (FARE 2022), National Institute of Health, Bethesda, Maryland
• 2017, Postdoctoral Travel award (Award of $500) from Cornell University attend Sperm Biology Meeting held at Sheffield, UK
• 2014-2015, Senior Research Fellowship from University Grants Commission Research Fellowship in Science for Meritorious Students
• 2012-2014, Junior Research Fellowship from University Grants Commission Research Fellowship in Science for Meritorious Students
• 2011, Qualified GATE (Graduate Aptitude Test in Engineering)
• 2011-2012, Graduate Research Fellowship, Banaras Hindu University, India
• 2010, Honorable Mention in Brain Awareness Week, Banaras Hindu University, India
  
  Others
• Society Service and Memberships: Indian Society of Cell Biology, Genetics Society of America, Society for the Study of Evolution, Society of Molecular Biology and Evolution, Animal Behavior Society
• Editorial and Peer Review Services:
  • Review Editor in Frontiers in Insects Science, Frontiers in Endocrinology, Frontiers in Physiology (special section on Reproduction)
  • Reviewer in journals such as Veterinary Sciences, Advances in Bioengineering and Biotechnology, STAR Protocols, Journal of Clinical Medicine, Animals, Genes, Biology, Cells, Insects, Life, Scientific Reports, Medicina, Journal of Personalized Medicine, International Journal of Molecular Sciences, Medical Research Archives, Journal of Scientific Research Reports, Asian Journal of Research in Biochemistry, Genetics and Molecular Biology, Plant Cell Biotechnology and Molecular Biology

Runa Kuley is an Assistant Professor in the Center for Life Sciences at Mahindra University. She earned her PhD from Wageningen University and Research in the Netherlands. During her PhD she characterized the Dutch Q-fever outbreak strains of Coxiella burnetii bacteria, which led to a better understanding of the host-pathogen interactions and elucidated novel virulence mechanisms of the outbreak strains. After receiving her PhD, she joined the Department of Immunology at the University of Washington, Seattle, as a postdoctoral fellow, where she investigated the role of B cell activating factor (BAFF) in generating protective B cell responses during bacterial and viral infections. In addition, she investigated the pathogenic role of BAFF in the development of autoimmune diseases. Her work led to the identification of a crucial link between the innate and B cell adaptive immune systems. In her second postdoctoral fellowship, she joined the Division of Rheumatology at the University of Washington where she explored the role of neutrophils and mitochondria in the pathogenesis of several autoimmune diseases and examined the clinical utility of neutrophil activation biomarkers in rheumatic disease. Research in her lab focuses on understanding the host-pathogen interactions and deciphering the contributions of immune cell dysregulation in the pathogenesis of rheumatic diseases.

• Ph.D.: Wageningen University and Research, The Netherlands (Sep 2011 – May 2017)
• M.Sc. Animal Biotechnology: University of Hyderabad, Hyderabad (2009 – 2011)
• B.Sc. Biotechnology: Osmania University, Hyderabad (2006-2009)

• Kuley, R., Duvvuri, B., Wallin, J.J., Bui, N., Adona, M.V., O’Connor, N.G., Sahi, S.K., Stanaway, I.B., Wurfel, M.M., Morrell, E.D., et al. (2023). Mitochondrial N-formyl methionine peptides contribute to exaggerated neutrophil activation in patients with COVID-19. Virulence 14, 2218077. 10.1080/21505594.2023.2218077.
• Michailidou, D., Kuley, R., Wang, T., Hermanson, P., Grayson, P.C., Cuthbertson, D., Khalidi, N.A., Koening, C.L., Langford, C.A., McAlear, C.A., et al. (2023). Neutrophil extracellular trap formation in anti-neutrophil cytoplasmic antibody-associated and large-vessel vasculitis. Clin. Immunol. 249, 109274. 10.1016/j.clim.2023.109274.
• Giordano, D., Kuley, R., Draves, K.E., Elkon, K.B., Giltiay, N.V., and Clark, E.A. (2023). B cell-activating factor (BAFF) from dendritic cells, monocytes and neutrophils is required for B cell maturation and autoantibody production in SLE-like autoimmune disease. Front. Immunol. 14. https://doi.org/10.3389/fimmu.2023.1050528

• Michailidou D, Duvvuri B, Kuley R, Cuthbertson D, Grayson PC, Khalidi NA, et al. Neutrophil activation in patients with anti-neutrophil cytoplasmic autoantibody-associated vasculitis and large-vessel vasculitis. Arthritis Res Ther 2022;24:160.
• Michailidou, D., Johansson, L., Kuley, R., Wang, T., Hermanson, P., Rantapää-Dahlqvist, S., and Lood, C. (2022). Immune complex-mediated neutrophil activation in patients with polymyalgia rheumatica. Rheumatology, keac722. 10.1093/rheumatology/keac722.

• Kuley R, Stultz RD, Duvvuri B, Wang T, Fritzler MJ, Hesselstrand R, et al. N-Formyl Methionine Peptide-Mediated Neutrophil Activation in Systemic Sclerosis. Front Immunol 2022;12. https://doi.org/10.3389/fimmu.2021.785275
• Kuley R*, Draves KE, Fuller DH, Giltiay NV, Clark EA, Giordano D*. B cell activating factor (BAFF) from neutrophils and dendritic cells is required for protective B cell responses against Salmonella typhimurium infection. PLoS ONE (2021) 16:e0259158. doi:10.1371/journal.pone.0259158
• Giordano, D., Kuley, R., Draves, K.E., Roe, K., Holder, U., Giltiay, N.V., and Clark, E.A. (2020). BAFF Produced by Neutrophils and Dendritic Cells Is Regulated Differently and Has Distinct Roles in Antibody Responses and Protective Immunity against West Nile Virus. J. Immunol. 1950 204, 1508–1520.
• Kuley R, Smith HE, Smits M, Jan Roest HI, Bossers A. Genome plasticity and polymorphisms in critical genes correlate with increased virulence of Dutch outbreak-related Coxiella burnetii strains. Front. Microbiol. 8:1526. doi: 10.3389/fmicb.2017.01526Ammerdorffer A, Kuley R, Dinkla A, Joosten L, Toman R, Jan Roest HI, Sprong T, Rebel JM. Coxiella burnetii isolates originating from infected cattle induce a more pronounced pro-inflammatory cytokine response compared to isolates from infected goats and sheep. Pathogens and Disease. 2017 Apr 06 : 75 (4): ftx040.
• Kuley R, Smith HE, Janse I, Harders FL, Baas F, Schijlen E, Nabuurs-Franssen MH, Smits MA, Roest HI, Bossers A. First complete genome sequence of the Dutch veterinary Coxiella burnetii strain NL3262, originating from the largest global Q fever outbreak, and draft genome sequence of its epidemiologically linked chronic human isolate NLhu3345937. Genome Announcements. 2016 Apr 21;4(2). pii: e00245-16. doi: 10.1128/genomeA.00245-16.

• Kuley R, Bossers de-Vries, R, Smith HE, Smits M, Jan Roest HI, Bossers A. Major differential gene regulation in Coxiella burnetii between in vivo and in vitro cultivation models. BMC Genomics. 2015;16:953. DOI: 10.1186/s12864-015-2143-7.
• Kuley R, Smith HE, Frangoulidis D, Smits MA, Jan Roest HI, Bossers A (2015) Cell-free propagation of Coxiella burnetii does not affect its relative virulence. PLoS ONE 10(3): e0121661. doi:10.1371/journal.pone.0121661.

Book Chapter:

• Ammerdorffer A, Kuley R, Jan Roest HI. Physiopathology of Coxiella burnetii infection and host immunologic response. Book Title: The Principles and Practice of Q Fever: The One Health Paradigm. 2017. ISBN: 978-1-53610-868-2

• 2022- Present Assistant Professor Center for Life Sciences Mahindra University.
• Postdoctoral fellow: Division of Rheumatology, University of Washington, Seattle, USA (July 2020 – Dec 2021)
• Postdoctoral fellow: Department of Immunology and Division of Rheumatology, University of Washington, Seattle, USA (June 2017 – June 2020)

Research in our group is focused on understanding the immune system dysregulation in inflammatory and autoimmune diseases. Our goal is to decipher the contributions of various immune cells, with emphasis on neutrophils and their derived components, in promoting systemic inflammation and in immune dysregulation such as the development of pathogenic autoreactive B cells in autoimmune diseases. The overarching goals of these projects are to gain mechanistic insights into these processes and identify the therapeutic targets. We are also interested in the identification of neutrophil- and mitochondrial-derived biomarkers of autoimmune diseases for diagnostics purposes. In addition, our lab is interested in studying host-pathogen interactions with a focus on zoonotic diseases (transmitted from animals to humans). Our goal is to understand the biology and virulence mechanisms of the pathogenic agents and associated protective immune responses from the host. We utilize interdisciplinary approaches including microbiology, omics technologies, molecular biology, biochemical methods, and immunology to answer these research questions.

Pijus K. Barman earned his Ph.D. in Immunology from the Institute of Life Sciences, Bhubaneswar, India. During his doctoral research in the laboratory of Prof. B. Ravindran he studied the regulation of inflammatory responses during tissue injury and infection. His first postdoctoral training in Prof. Timothy Koh’s lab at the University of Illinois at Chicago was focused on studying monocyte production (monopoiesis) during normal and diabetic wound healing. He then moved to Prof. Helen Goodridge’s lab at Cedars-Sinai Medical Center, in Los Angeles where he explored how aging impacts monocyte ontogeny and phenotype. Dr. Barman has joined the Center for Life Sciences, Mahindra University, in September 2022 as an Assistant Professor.

• B.Sc (2003-2006); University of Calcutta, Calcutta, West Bengal, India
• M.Sc (2006-2008); Guru Nanak Dev University, Amritsar, Punjab, India
• Ph.D (2009-2016); Institute of Life Sciences, Bhubaneswar, Odisha, India

• Kang S, Andrews AE, Ko EY, Shin JE, Nance KJ, Barman PK, Heeger PS, Benayoun BA, Goodridge HS. C3a drives sex-dimorphic metabolic and transcriptional rewiring of microglia during aging. Journal of Neuroinflammation. 2024 Jun 05; 21, 150.

• Barman PK,Shin JE, Lewis SA, Kang S, Wu D., Wang Y, Yang X, Nagarkatti PS, Nagarkatti M, Messaoudi I, Benayoun BA, Goodridge HS. Production of MHCII-expressing classical monocytes increases during aging in mice and humans. Aging Cell. 2022 Aug 30; 00:e13701.
• Barman PK, Goodridge HS. Microbial sensing by hematopoietic stem and progenitor cells. Stem Cells, 2022 Jan 19; 40, 14–21.

• Barman PK,and Koh TJ. Macrophage Dysregulation and Impaired Skin Wound Healing in Diabetes. Front Cell Dev Biol, 2020 Jun 26; 8, 528.

• Barman PK, Urao N, and Koh TJ. Diabetes induces myeloid bias in bone marrow progenitors associated with enhanced wound macrophage accumulation and impaired healing. J Pathol, 2019 Jul 18; 249, 435-446.
• Wolf AA, Yanez A, Barman PK,and Goodridge HS. The Ontogeny of Monocyte Subsets. Front Immunol, 2019 Jul 17; 10, 1642.
• Barman PK, Pang J, Urao N, and Koh TJ. Skin Wounding-Induced Monocyte Expansion in Mice Is Not Abrogated by IL-1 Receptor 1 Deficiency. J Immunol, 2019 March 25; 202, 2720-2727. (Featured in “In this issue – Skin Wounding Sparks Monocytes”).

• Fang MM, Barman PK,Thiruppathi M, Mirza RE, McKinney RD, Deng J, Christman JW, Du X, Fukai T, Ennis WJ, et al. Oxidant Signaling Mediated by Nox2 in Neutrophils Promotes Regenerative Myelopoiesis and Tissue Recovery following Ischemic Damage. J Immunol, 2018- Sep 18; 201, 2414-2426.

• Barman PK,Mukherjee R, Prusty BK, Suklabaidya S, Senapati S, and Ravindran B. Chitohexaose protects against acetaminophen-induced hepatotoxicity in mice. Cell Death Dis, 2016 Jul 4; 7, e2224.

• Mukherjee R, Barman PK,Thatoi PK, Tripathy R, Das BK, and Ravindran B. (2015). Non-Classical monocytes display inflammatory features: Validation in Sepsis and Systemic Lupus Erythematous. Sci Rep, 2015 Sep 11; 5, 13886.

• Pandey M, Borah A, Varghese M, Barman PK, Mohanakumar KP, and Usha R. Striatal dopamine level contributes to hydroxyl radical generation and subsequent neurodegeneration in the striatum in 3-nitropropionic acid-induced Huntington’s disease in rats. Neurochem Int, 2009 May 3; 55, 431-437.

Book Chapter

• Barman, P.K., Koh, T.J.Bone marrow monopoiesis and wound healing in diabetes. Academic Press, 2020, 535-553. Wound Healing, Tissue Repair, and Regeneration in Diabetes.

• 2022- Present Assistant Professor Center for Life Sciences Mahindra University.
• Postdoctoral Research Scientist (2019-2022); Cedars-Sinai Medical Center, Los Angeles, California, USA
• Project Scientist (2022); Cedars-Sinai Medical Center, Los Angeles, California, USA
• Postdoctoral Research Associate (2016-2019); University of Illinois at Chicago, Chicago, Illinois, USA

• Monocytes and Infectious Diseases
  
  Human and animal communities residing in infectious disease endemic regions can be classified into three categories; (i) “symptomatic carriers”, who develop infections with pathologies and hence are susceptible to the infections, (ii) “asymptomatic carriers”, who are infected but without any pathology and hence are tolerant to the infections and (iii) “uninfected”, who are exposed to the pathogens but are not infected and hence are resistant to the infections. We are interested in studying the role of monocyte subsets in “susceptibility versus resistance versus tolerance” against infectious pathogens using mouse models of infectious diseases and human patients.
  
• Bone Marrow Microenvironment and Hematopoiesis
  
  Hematopoietic stem cells (HSCs) reside in bone marrow niche which contains various components including mesenchymal stromal cells (MSCs) and sympathetic nerves. Increased β2-adrenergic receptor signaling from sympathetic nerves to MSCs is believed to alter HSCs in turn to produce more myeloid cells during aging and metabolic stress. We are interested in defining the mechanisms involved in increased β2-adrenergic receptor signaling in the bone marrow during aging and metabolic stress using in vitro cell cultures and mouse models.
  
• Aging and Cardiovascular diseases
  
  Aging leads to higher risk of cardiovascular diseases such as atherosclerosis by yet unknown mechanism. Various immune cells including monocytes play important roles in the formation of atherosclerotic plaque in blood vessels ultimately causing obstruction of blood flow and necrosis of downstream tissues. In our laboratory, we are investigating the mechanism underlying functionally altered monocytes in higher risk of atherosclerosis during aging.

Sanjeev received Ph.D. in Molecular Cell Biology from the University of Groningen in the Netherlands. During his doctoral research in the laboratory of Prof. Ida J. van der Klei he studied the role of peroxisomes in cellular aging. He completed his postdoctoral training in John Aitchison’s laboratory at the Institute for Systems Biology and Seattle Children’s Research Institute, Seattle, USA. His postdoctoral work focused on understanding the role of the nuclear pore complex in gene regulation and chromatin organization. He joined the Center for Life Sciences, Mahindra University, as an Assistant Professor in January 2023.

• Ph.D.: University of Groningen, The Netherlands (Sep 2010 – Dec 2015)
• M.Sc. Animal Biotechnology: University of Hyderabad, Hyderabad (2008 – 2010)
• B.Sc. Biotechnology: Patna University, Hyderabad (2005-2008)

Google scholar link: https://scholar.google.com/citations?user=0n58EkAAAAAJ&hl=en&oi=sraKumar, S., Neal, M., Li, S., Navare, A., Eeuwen, T., Wozniak, R., Mast, F., Rout, M., and Aitchison, J. (2023). Nuclear pore complexes mediate subtelomeric gene silencing by regulating PCNA levels on chromatin. Journal of Cell Biology. 10.5555/12345678.

• Kumar, S., Neal. M. L., Li. S., Navare A.T., Mast F.D., Rout. M.P., and Aitchison J.D. (2022). The nucleoporin Nup170 mediates subtelomeric gene silencing through the Ctf18-RFC complex and PCNA. (bioRxiv). https://doi.org/10.1101/2022.06.17.496627
• Xu, J., Kumar, S., Hua, N., Kou, Y., Lei, X., Rout, M.P., Aitchison, J.D., Alber, F., and Chen, L. (2022). Cryomilling Tethered Chromatin Conformation Capture reveal new insights into inter-chromosomal interactions. (bioRxiv). https://doi.org/10.1101/2022.02.03.478915.

• Kumar, S., de Boer, R., and van der Klei, I.J. (2018). Yeast cells contain a heterogeneous population of peroxisomes that segregate asymmetrically during cell division. J. Cell Sci. (2018) doi:10.1242/jcs.207522.

• Kumar, S., Singh, R., Williams, C. P. and van der Klei, I. J. (2016). Stress exposure results in increased peroxisomal levels of yeast Pnc1 and Gpd1, which are imported via a piggy- backing mechanism. BBA – Mol. Cell Res. 1863, 148–156.

• Lefevre, S. D., Kumar, S. and van der Klei, I. J. (2015). Inhibition of peroxisome fission, but not mitochondrial fission, increases yeast chronological lifespan. Cell Cycle 14, 1698–1703.

• Kumar, S., Kawałek, A. and van der Klei, I. J. (2014). Peroxisomal quality control mechanisms. Curr. Opin. Microbiol. 22, 30–37.

• Kumar, S., Lefevre, S. D., Veenhuis, M. and van der Klei, I. J. (2012). Extension of Yeast Chronological Lifespan by Methylamine. PLoS ONE 7, e48982.

• 2025- Present Associate Professor Center for Life Sciences Mahindra University.
• 2023- 2025 Assistant Professor Center for Life Sciences Mahindra University.
• Research Scientist III: Seattle Children’s Research Institute, Seattle, USA (Jan 2020 – Jan 2023)
• Postdoctoral fellow: Seattle Children’s Research Institute, Seattle, USA (June 2017 – Jan 2020)
• Post Doctoral Fellow: Institute for Systems Biology, Seattle, USA (Dec 2015 – June 2017)

• We use classical molecular cell biology and systems biology approaches to uncover the biology of two important cellular components: the nuclear pore complex and peroxisomes.
• Nuclear pore complexes (NPCs) are large protein assemblies which control transport of macromolecules into and out of the nucleus. In addition, NPCs have roles in regulating chromatin organization and other crucial cellular processes. Alternations in functioning of the NPC are associated with several diseases. Our lab is interested in dissecting the molecular mechanisms of various functions associated with the NPC and diseases that occur due to abnormalities in it.
• Peroxisomes are cellular organelles important for fatty acid and reactive oxygen species (ROS) metabolism. Peroxisomal dysfunction has been linked with aging, neurodegenerative diseases, and metabolic disorders. We are interested in understanding the molecular details of the processes that lead to peroxisomal defects causing various diseases.

• Ph.D. (Computational and Systems Biology) School of Computational and Systems Biology, Jawaharlal Nehru University, New Delhi, India.
• M.Tech. (Computational and Systems Biology) School of Computational and Integrative Sciences, Jawaharlal Nehru University, New Delhi, India.
• M.Sc (Mathematics) Banaras Hindu University, Varanasi.
• B.Sc (Mathematics, Physics, Chemistry) Ewing Christian College, Allahabad University.

Journal Articles

• Kuley, R., Duvvuri, B., Hasnain, S., Dow, E. R., Koch, A. E., Higgs, R. E., Krishnan, V., & Lood, C. (2025). “Neutrophil Activation Markers and Rheumatoid Arthritis Treatment Response to the JAK1/2 Inhibitor Baricitinib.” Arthritis & Rheumatology, 77(4), 395–404.
• Hasnain, S., Mugnai, M. L., & Thirumalai, D. (2021). “Effects of Gold Nanoparticles on the Stepping Trajectories of Kinesin.” The Journal of Physical Chemistry B, 125(37), 10432–10444.
• Hasnain, S., Harbola, U., & Bandyopadhyay, P. (2018). “A Memory-based Random Walk Model to Understand Diffusion in Crowded Heterogeneous Environments.” International Journal of Modern Physics B, 32(16), 1850193.
• Hasnain, S., & Bandyopadhyay, P. (2015). “An Analytical Correlated Random Walk Model and Its Application to Understand Subdiffusion in Crowded Environments.” The Journal of Chemical Physics, 143(11).
• Hasnain, S., McClendon, C. L., Hsu, M. T., Jacobson, M. P., & Bandyopadhyay, P. (2014). “A New Coarse-grained Model for E. coli Cytoplasm: Accurate Calculation of the Diffusion Coefficient of Proteins and Observation of Anomalous Diffusion.” PLoS One, 9(9), e106466.
• Hasnain, S., Jacobson, M. P., & Bandyopadhyay, P. (2014). “A Comparative Brownian Dynamics Investigation Between Small Linear and Circular DNA: Scaling of Diffusion Coefficient with Size and Topology of DNA.” Chemical Physics Letters, 591, 253–258.

Book Chapters

• Mirza, S., Pandey, P., Hasnain, S., & Ahmad, S. Emerging Topics in Protein–DNA Interactions.
• Pandey, P., Hasnain, S., & Ahmad, S. Protein–DNA Interactions.

Conference Proceedings

Hasnain, Sabeeha, et al. “A Computational Model for E. coli Cytoplasm: Diffusion and Hydrodynamics.” Biophysical Journal 108.2 (2015): 116a-117a.

Google Scholar Profile: https://scholar.google.com/citations?user=7Eupf70AAAAJ&hl=en

• Assistant Professor Center for Life Sciences Mahindra University: (2023 – Present)
• Scientist, Metflux Research Pvt. Ltd: (2022-2023)
• National Postdoctoral fellow, Ashoka University, Supervisor: Prof. Gautam Menon: (2021-2022)
• 2017-2020 Postdoctoral Fellow, Department of Chemistry, The University of Texas at Austin, Austin, TX, USA. Supervisor: Prof. Devarajan (Dave) Thirumalai: (2017-2020)

• Our research centers on comprehending complex biological phenomena through the development and utilization of coarse-grained and analytical models. By employing an interdisciplinary approach, we aim to address biological challenges effectively.
• Furthermore, we have a specific interest in utilizing neural networks to gain insights into the search mechanism involved in the binding of transcription factors to DNA. Additionally, we are actively investigating the potential of these techniques to accurately predict drug-target affinity.

Awards

• International Travel award from Biophysical Society of USA to attend 59th Annual Biophysical Society meeting held at Baltimore, Maryland, USA (2015).
• UGC Maulana Azad fellowship JRF (2011-2013) and SRF (2013-2016) during Ph. D.
• International travel award from SERB India.
• DBT fellowship during M. Tech.
• Gate qualified (2009) in Mathematics.

Bipin finished his Ph.D. in Bioinformatics from IIIT-Hyderabad. During his Ph.D., he worked on elucidating the molecular mechanisms of mutation-induced thermostability in industrially important bacterial lipases through molecular simulations. His broad area of specialization is computational drug discovery and structural bioinformatics. He received a highly competitive GPU hardware grant from NVIDIA corporation, USA in 2017 for his research work. He was also part of the project team winning the consolation prize in the highly competitive National Drug Discovery Hackathon for COVID-19 launched by MHRD and Govt. of India in 2020. He is currently working on elucidating the molecular basis of the activity of bioactive peptides for infectious and neglected tropical diseases, along with his team of Ph.D. research scholars and external collaborators.

• Ph.D. Bioinformatics (2009-2017) IIIT-Hyderabad, Telangana
• M.Sc. Bioinformatics (2006-2008) University of Allahabad, U.P.
• B.Sc. Chemistry, Botany, Zoology (2003-2006) University of Allahabad, U.P.

• Wang R, Li Z, Liu X, Singh B, Chauhan RS, Duan Y, Xue J, Kumar V, et al. A novel transcription factor PtMYB77 from Pinellia ternata enhances heat tolerance in Arabidopsis by inducing early expression of heat shock factor genes. Industrial Crops and Products 227:120791, 2025.
• Jha K, Kumar A, Bhatnagar K, Patra A, Bhavesh NS, Singh B, et al. Modulation of Krüppel-like factors (KLFs) interaction with their binding partners in cancers through acetylation and phosphorylation. Biochimica et Biophysica Acta (BBA) – Gene Regulatory Mechanisms 1867(1):195003, 2024.
• Saraswat A, Sharma U, Gandotra A, Wasan L, Artham S, Maitra A, … Singh B. Pred-AHCP: Robust feature selection-enabled sequence-specific prediction of Anti-Hepatitis C peptides via machine learning. Journal of Chemical Information and Modeling 64(24):9111–9124, 2024. Chakrabarty P, Negi S, Andrés RM, Favaro B, Singh B, Hilleary R, et al. Facilitating conservation. Science 356(6335):242–244, 2017. Gupta A, Singh MS, Singh B. Deciphering the functional role of clinical mutations in ABCB1, ABCC1, and ABCG2 ABC transporters in endometrial cancer. Frontiers in Pharmacology 15:1380371, 2024.
• Nemati, M., Singh, B., Mir, R.A. et al. (2022) Plant-derived extracellular vesicles: a novel nanomedicine approach with advantages and challenges. Cell Commun Signal 20(1), 1-16.
• Maitra, A., & Singh, B. (2022). Interpreting force response patterns of a mechanically driven crystallographic phase transition. Phys Rev Mater, 6(4), 043404.
• Singh, B., & Barman, S. (2022). Rapid and precise discrimination between pure and adulterated commercial Indian Honey brands using FTIR spectroscopy and principal component analysis. Current Nutrition & Food Science, 18 (9), 780-784.
• Barman S, Singh B, Bag A, Patel AS, Chakraborti A, Rana A. (2021). Visible light driven photocatalytic degradation of Methyl Orange by Fe2O3-BiOCl0.5Br0.5 composite photocatalyst. Asia-Pac J Chem Eng, 16(6): e2715.
• Singh, B. Role of key point Mutations in Receptor Binding Domain of SARS-CoV-2 Spike Glycoprotein. (2020). Infectious Disorders – Drug Targets, 21(4), 640-642.
• Bobbili, K. B., Singh, B., Narahari, A., Bulusu, G., Surolia, A., Swamy, M. J. Chitooligosaccharide binding to CIA17 (Coccinia indica agglutinin): Thermodynamic characterization and formation of higher order complexes. (2019). Int. J. Biol. Macromol., 137:774-782.
• Farhi, A., and Singh, B. (2016). Calculation of molecular free energies in classical potentials. N. J. Phys., 18 023039.
• Farhi, A., and Singh, B. (2016). A novel method to calculate relative free energy of solvation and binding of similar molecules. Comp. Phys. Commun., 212, 132–145.
• Singh, B., Bulusu, G., and Mitra, A. (2016) Effects of point mutations on the thermostability of B. subtilis lipase: Investigating Nonadditivity. J. Comput. Aided Mol. Des., 30(10), 899-916.
• Singh, B., Bulusu, G., and Mitra, A. (2015) Understanding the Thermostability and Activity of Bacillus subtilis Lipase mutants: Insights from Molecular Dynamics Simulations. J. Phys. Chem. B., 119(2), 392–409.

Preprints

• Sharma, V., Chhatwal, S., & Singh, B. (2022). An Explainable Artificial Intelligence-based Prospective Framework for COVID-19 Risk Prediction. medRxiv. https://doi.org/10.1101/2021.03.02.21252269

Conference Publications

• M Zhong, T Hu, Y Jiao, SZ Dhuliawala, B Singh. Drug Repositioning via Text Augmented Knowledge Graph Embeddings. https://openreview.net/forum?id=qI-IS8DPq_N NeurIPS 2021. AI for Science Workshop.

Book Chapters

• Aditi Sen De: Inspiring Many Lives. Vigyan Vidushi, Vigyan Prasar, DST, GoI.
• Meena Mahajan: Intriguing, Curious but Logical. Vigyan Vidushi, Vigyan Prasar, DST, GoI.

Google Scholar: https://scholar.google.co.in/citations?user=RROC3RsAAAAJ&hl=en

ResearchGate: https://www.researchgate.net/profile/Bipin-Singh-11

• Associate Professor, Centre for Life Sciences, Mahindra University, Hyderabad, Telangana (August 2025 – Present).
• Assistant Professor, Centre for Life Sciences, Mahindra University, Hyderabad, Telangana (June 2023 – August 2025).
• Assistant Professor, Department of Biotechnology, Bennett University, Greater Noida, Uttar Pradesh (October 2021 – June 2023).
• Assistant Professor, Department of Applied Sciences, BML Munjal University, Gurugram, Haryana (August 2017 – October 2021).

• Computational Drug Discovery
• Computational Protein & Enzyme Engineering
• AI and ML for Bioinformatics
• Biological Networks
• NGS Data Analysis for Targeted Therapy

Aruna Kumar Chelluboyina, Ph.D., is as an Assistant Professor in Center for Lifesciences at Mahindra University, Hyderabad. He obtained his Ph.D. in Biotechnology from Indian Institute of Technology Madras, Chennai in 2016. Post-Ph.D., he completed his postdoctoral training from 2017 to 2023 at three different eminent research institutes in USA – Harvard Medical School, Cleveland Clinic and Case Western Reserve University.
His background in research covers broad area of translational molecular biology in human diseases. His research expertise includes molecular signaling in human cancers, gene editing and advanced gene therapy approaches for molecular intervention in various human diseases. His research work has been published in high impact journals, and he is a passionate teacher.

• Ph.D. in Biotechnology from Indian Institute of Technology Madras, Chennai (2011-16).
• Masters in Medical Biotechnology from University of Hyderabad, Hyderabad (2007-09).
• Masters in Biochemistry from Andhra University, Vishakhapatnam (2003-05).
• Bachelors in Biology from Andhra University, Vishakhapatnam (2000-03).

• 2023 – Present Assistant Professor Center for Life Sciences Mahindra University.
• Postdoctoral Research Fellow, 2022-23, Grousbeck Gene Therapy Center, Mass Eye and Ear, Department of Ophthalmology, Harvard University, USA: (2022)
• Postdoctoral Research Fellow, 2021-22, Department of Inflammation and Immunity, Lerner Research Institute, Cleveland Clinic, USA: (2021-2022)
• Postdoctoral Research Associate, 2017-20, Case Comprehensive Cancer Center, Case Western Reserve University, USA: (2017-2020)
• Research Associate, 2016-17, Department of Biotechnology, Indian Institute of Technology Madras, Chennai: (2016-2017)
• Scientist, 2009-11, Ventura Institute of Biosciences, Hyderabad: (2009-11)
• Lecturer in Biochemistry, 2005-2007, Adithya Group of Institutions, Rajahmundry, Andhra Pradesh: (2005-2007)

• Molecular Signaling
  The onset and progression of the disease in cancers is caused by certain molecular drivers. Using recently advanced methods like CRISPR screening and other whole-genome targeted approaches in appropriate disease models, we aim to delineate the driver genes and explore the potential of identified candidates as biomarkers and targets for therapeutic intervention and change the overall outcome of the disease.
• Gene Editing and Gene Therapy
  Gene therapy treatments combined with latest cutting-edge genome editing technologies like CRISPR are being developed by scientists to prevent and treat diseases in humans. Recently developed advanced genome editing technologies have the potential to cure many human diseases with genetic basis. Lately, FDA has approved gene therapy-based drugs for hereditary diseases like Spinal Muscular Atrophy, IRDs etc. Here, we aim to develop and optimize adeno-associated viral vector (AAV)-based gene therapies based on the needs of certain types of inherited genetic disorders and cancers.