Sanjeev Kumar received his Ph.D. in Molecular Cell Biology from the University of Groningen in the Netherlands. During his doctoral research in the laboratory of Prof. Ida J. van der Klei he studied the role of peroxisomes in cellular aging. He completed his postdoctoral training in John Aitchison’s laboratory at the Institute for Systems Biology and Seattle Children’s Research Institute in Seattle, USA. His postdoctoral work focused on understanding the role of the nuclear pore complex in gene regulation and chromatin organization. He joined the Center for Life Sciences, Mahindra University, as an Assistant Professor in January 2023.
Kumar, S., Neal. M. L., Li. S., Navare A.T., Mast F.D., Rout. M.P., and Aitchison J.D. (2022). The nucleoporin Nup170 mediates subtelomeric gene silencing through the Ctf18-RFC complex and PCNA. (bioRxiv). https://doi.org/10.1101/2022.06.17.496627
Xu, J., Kumar, S., Hua, N., Kou, Y., Lei, X., Rout, M.P., Aitchison, J.D., Alber, F., and Chen, L. (2022). Cryomilling Tethered Chromatin Conformation Capture reveal new insights into inter-chromosomal interactions. (bioRxiv). https://doi.org/10.1101/2022.02.03.478915.
Kumar, S., de Boer, R., and van der Klei, I.J. (2018). Yeast cells contain a heterogeneous population of peroxisomes that segregate asymmetrically during cell division. J. Cell Sci. (2018) doi:10.1242/jcs.207522.
Kumar, S., Singh, R., Williams, C. P. and van der Klei, I. J. (2016). Stress exposure results in increased peroxisomal levels of yeast Pnc1 and Gpd1, which are imported via a piggy- backing mechanism. BBA - Mol. Cell Res. 1863, 148–156.
Lefevre, S. D., Kumar, S. and van der Klei, I. J. (2015). Inhibition of peroxisome fission, but not mitochondrial fission, increases yeast chronological lifespan. Cell Cycle 14, 1698–1703.
Kumar, S., Kawałek, A. and van der Klei, I. J. (2014). Peroxisomal quality control mechanisms. Curr. Opin. Microbiol. 22, 30–37.
Kumar, S., Lefevre, S. D., Veenhuis, M. and van der Klei, I. J. (2012). Extension of Yeast Chronological Lifespan by Methylamine. PLoS ONE 7, e48982.
We use classical molecular cell biology and systems biology approaches to uncover the biology of two important cellular components: the nuclear pore complex and peroxisomes.
Nuclear pore complexes (NPCs) are large protein assemblies which control transport of macromolecules into and out of the nucleus. In addition, NPCs have roles in regulating chromatin organization and other crucial cellular processes. Alternations in functioning of the NPC are associated with several diseases. Our lab is interested in dissecting the molecular mechanisms of various functions associated with the NPC and diseases that occur due to abnormalities in it.
Peroxisomes are cellular organelles important for fatty acid and reactive oxygen species (ROS) metabolism. Peroxisomal dysfunction has been linked with aging, neurodegenerative diseases, and metabolic disorders. We are interested in understanding the molecular details of the processes that lead to peroxisomal defects causing various diseases.
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