B.Tech in Bio – Technology Program

Overview

The biotechnology sector, mainly due to its multidisciplinary approach, holds the potential to provide an array of solutions for challenges in various sectors such as health, agriculture, environment, energy and industrial processes. The global biotechnology market size was valued at USD 752.88 billion in 2020 and is expected to expand at a compound annual growth rate (CAGR) of 15.83% from 2021 to 2028.

By 2025, contribution of the Indian biotechnology industry in the global biotechnology market is expected to increase to ~19%. India is among the top 12 biotechnology destinations in the world and the 3rd largest in Asia-Pacific. The Indian bioeconomy grew from US$ 62.5 billion in 2019 to US$ 70.2 billion in 2020 at a growth rate of 12.3% and is likely to register a CAGR of 16.4% to reach US$ 150 billion by 2025.

The Indian biotech industry consists of 4,240 biotech start-ups and is expected to grow to 10,000 by 2024. As of February 2022, India has almost 5000 biotech companies. India has 665 FDA-approved plants outside of the US, which is the highest in the world. India also has 44% share of the global abbreviated new drug applications (ANDA) and >1400 manufacturing plants which comply with WHO requirements. As of 2020, biopharmaceuticals contributed 62% to the Indian bioeconomy, followed by bio-agriculture (16%), bio-services (15%) and bio-industrial (7%).

4-Yr B.Tech. Biotechnology program with possibility to continue into integrated 5-Yr M.Tech. Biotechnology.

Specializations

Delivered through specific courses and intensive industry project.

Pharmaceutical Biotechnology

Pharmaceutical Biotechnology

Pharmaceutical biotechnology is a relatively new and growing field in which the principles of biotechnology are applied to the development of drugs. A majority of therapeutic drugs in the current market are bioformulations, such as antibodies, nucleic acid products and vaccines. Such bioformulations are developed through several stages that include: understanding the principles underlying health and disease; the fundamental molecular mechanisms governing the function of related biomolecules; synthesis and purification of the molecules; determining the product shelf life, stability, toxicity and immunogenicity; drug delivery systems; patenting; and clinical trials. The domain encompasses knowledge in rDNA technology such as cloning genes encoding the protein of interest into an appropriate cloning vector, finding suitable host cells to express the protein (eg Escherichia coli, yeast, insect cells, plants, or animals), designing protocols to obtain highly pure proteins (eg chromatographic purification via size-exclusion, ion-exchange, hydrophobic interaction or affinity) and protein engineering to generate mutants and/or facilitate post-translational modifications.

Green Chemicals & Bio-Products

Green Chemicals & Bio-Products

A range of environment friendly products can be produced by biotechnology. These are known as green products or sustainable alternatives of petrochemical derived products. This specialization will cover production of green products ranging from enzymes and biocatalysts, biofuels, biobased platform chemicals, among others. Global market of enzyme is worth of $ 10.6 billion and it is expected to reach $14.9 billion by 2027. Similarly, global market of biofuels is worth of $ 141.32 billion and it is expected to reach $ 307.01 billion by 2030. Therefore, biotech professionals specialized in these fields are expected to have excellent employment opportunities in future.

Digital Agriculture

Digital Agriculture

The Global Digital Agriculture market is expected to grow at a compound annual growth rate of 10.26% over the forecast period to reach a market size of US$20.713 billion in 2025 from US$11.527 billion in 2019. Digital Agriculture is known as the use of novel, advanced and innovative technologies, integrated into one specific system or software, to allow various stakeholders such as farmers, researchers, and others, that are working within the agriculture system or a value chain, to enhance their crop yield and food production. The specialization focuses on; i) Gather farming data, including historical, predictive modelling and environmental insights to choose suitable crops with higher yields; ii) Measure performance of the site by capturing data in real time; iii) Use digital farming data (soil, crop health, weather, etc.) to provide decision support for using exact amount or water, nutrition and optimize pest control; iv) Increase farm’s economic and environmental sustainability; and v) Predict weather changes and react proactively.

Precision Medicine

Precision Medicine

The global precision medicine market size was valued at USD 66.1 billion in 2021 and is expected to reach USD 175.64 billion by 2030 and poised to grow at a compound annual growth rate (CAGR) of 11.5% during the forecast period 2022 to 2030. The genomics industry has a significant role to play in delivering on the promise of genomic medicine and its integration into healthcare. Precision medicine (PM) refers to tailoring of medical treatment depending on an individual’s genetic characteristics and relies on the use of data and genomics through diagnostic testing and analytics. It relies on the idea of the right intervention at the right dose to the right patient and at the right time. It is expected to deliver improved “quality use of medicines” resulting in improved quality of life for patients, as well as reduce adverse outcomes and drive down costs of treatment.

Gut microbiome

Gut microbiome

As humans, the number of microbial cells in our body outnumber our own cells by a ratio of 1.3:1. This diverse array of bacteria, fungi and viruses are called the microbiome. 95% of the microbiome resides in the gut and is in constant communication with the human systems. The gut microbiome is a very dynamic interactive community that plays a central role in human health and disease. The impact of this microbiome on human life ranges over nutrition, circadian rhythms, infectious disease, inflammatory disease, cancer, diabetes and even nervous system development. The gut microbiome is being explored extensively to identify diagnostic biomarkers for diseases such as diabetes and colon cancer as well as identifying their therapeutic potential. Gut microbiome modulation has been shown to have positive outcomes in treatments of obesity, auto-immune disorders and cardiovascular diseases. The Human Microbiome Market was valued at US$186.8 million in 2022 and is projected to grow at a CAGR of 25.0 % during the forecast period 2023-2033. In 2019, the Government of India initiated a Rs150 crore project called the Human Microbiome Project (HMP) to map the microbiome in Indian population. Applications of the gut microbiome in healthcare is a very promising area that can deliver solutions to many diseases and improve the overall quality of life.

Food processing and nutrition

Food processing and nutrition

The food processing market is projected to grow from USD 163.79 billion in 2022 to USD 400.43 billion in 2030 at a CAGR of 11.82%. Proper food processing can enhance the shelf life of food products. Such food products can also be fortified with essential nutrients so that they can provide essential dietary components that may not otherwise be easily obtained due to various constraints such as resource limitations. Understanding how the process optimization should be done economically while maintaining hygiene and nutritional quality of the food products can aid in providing food security to the growing population of the country.

Biopharmaceutical Technology

Biopharmaceutical Technology

Biopharmaceutical technology is a rapidly growing and emerging field where biotechnological principles are directly applied towards drug development for disease intervention. Majority (60%) of therapeutic drugs in the current market are bioformulations, such as antibodies, nucleic acid products, and vaccines. This field combines scientific principles from versatile domains such as understanding disease aetiology, biomolecular chemistry, biosynthesis and purification, formulation, assessing shelf life, stability, toxicity and immunogenicity, drug delivery systems, patenting, and clinical trials. Drawing from several deep-tech niches such as recombinant DNA technology, host system engineering, protein engineering, and immunology, this area with USD 478 billion market size (2023) is poised to see immense growth (9.2% CAGR) in the upcoming years. Some of the global market leaders in this field are Pfizer, AstraZeneca, Bristol Myers Squibb etc.

Biomanufacturing and Green Products

Biomanufacturing and Green Products

This field uses engineered biological systems for the preparation of chemicals and biological molecules with high market commercialization potential. Unlike traditional chemical synthesis, these production pathways and final commercial entity are considered “Green” as they often utilize raw materials of biological origin and the biproducts are also often biodegradable or reusable. It utilizes combinatorial technologies such as cell cultures, fermentation, metabolic network manipulation, enzyme engineering, ML, and automation engineering. Having a market size of USD 22 billion (2023) and 9.8% CAGR, this field is utilized in recombinant production of medical products & therapies, biomaterials of biomedical and agricultural importance, food & beverages, and specialty chemicals. Some of the global market leaders in this field are Unilever, Ansa Biotechnologies, Redbud labs etc.

Diagnostics and Biomarkers

Diagnostics and Biomarkers

Biomarker identification of chronic, infectious, and rare diseases and utilization of these biomarker for timely molecular diagnostics are a highly interdisciplinary area transcending the domains of medicine, engineering, chemistry, and biology. With direct application towards saving millions of lives, this field of market size USD 29 billion (2023) is considered an area with enormous growth potential (CAGR 8%). It combines state-of-the-art scientific advances and technologies from disease aetiology, electronics, physics, molecular recognition, chemical conjugation, microfluidics etc. Some of the global market leaders in this field are Abbott, Roche, Siemens, Qiagen etc.

Core Technical Competencies to be Developed Through the Program

Genomics

Omics technologies, novel applications of gene/ genome sequencing in diverse biotech domains.

Gene Editing

Gene cloning, genome editing, CRISPR, genetic disorders, gene therapy, gene silencing, transgenic plants and animals.

Precision Medicine

Genomics of genetic disorders, discovery of novel drug targets, cell therapy, drug delivery technologies.

Microfluidics

Lab-on-a chip i.e. militarized labs for rapid testing in biopharma drug screening and disease modelling, facilitating point-of-care diagnosis, paper-based microfluidics for diagnostics.

Biomanufacturing

Cell cultures, fermentation, recombinant production of medical products & therapies, biomaterials, food & beverages, specialty chemicals, ML in automation, precision biomanufacturing.

Synthetic Biology

Manipulating organisms at gene networks, cellular agriculture, microbiome-based solutions, cell factories to provide valuable biochemicals in pharma, materials, and food, mammalian synthetic biology.

Tissue Engineering

Tissue grafts to treat burns, organ transplanting, regenerative medicine, cultured meat, etc.

AI & Big Biological Data

Drug discovery, biomarkers, literature mining, images classification for rapid detection, medical scans, decision support in digital agritech.

GMP & Regulatory Affairs

Product quality, safety, regulatory procedures, etc.

Bioprinting

Bioprinters, bio-inks, bio-base materials, medical applications, vascular grafts from patient’s own cells for personalized medicine

Core Courses

Potential Job Profiles

  • Technical Solution Manager
  • Research Associate
  • Medical scientists
  • Biomedical Engineers
  • Microbiologists
  • R&D and Process Development Scientists

  • Biomanufacturing Specialists
  • Bioproduction Operators
  • Project Assistant
  • Project Management Engineer
  • Trainee Research Associate

  • Agricultural Consultant
  • Pursue higher education abroad

Semester I

Sr. No. Course Code Course Title L T P  Credits
1 BT 1101/BT 1102 Basic Mathematics /Introduction to Biology* 3 0 0 3
2 BT 1103 Introduction to Biotechnology 2 0 0 2
3 BT 1104 Chemistry of Biomolecules 3 0 2 4
4 PH 1103 Physics for BT & CB 3 1 2 5
5 ES 103 Earth and Environmental Sciences 2 0 0 2
6 HS 1101 English 0 3 0 3
7 HS 1102 Media Project 0 0 2 1.5
8 FS 1103 French- I 0 2 0 0.5
9 HS 1104 Introduction to Entrepreneurship 0 0 3 1
Total Credits 22

*For students with Bio or Math in 10+2

Semester II

S. No Course Code Course Title L T P  Credits
1 BT 1205 Genetics 2 1 2 4
2 BT 1206 Biodiversity & Global Conventions 1 0 0 1
3 BT 1207 Basic Mathematics II 3 1 0 4
4 EE 1204 Basic Electronics & Applications 2 1 2 4
5 CH 1202 Chemistry-II 2 0 2 3
6 CS 1101 Introduction to Computing 2 1 2 4
7 HS 1201 Entrepreneurship Practice 0 0 2 1
8 HS 1202 Professional Ethics 0 1 0 1
9 HS 1203 French-II 0 2 0 0.5
Total Credits 22.5

Semester III

S. No Course Code Course Title L T P Total Credits
1 BT 2108 Enzymes & Metabolism 3 0 2 4
2 BT 2109 Microbes & Immune Systems 4 0 2 5
3 BT 2110 Cell & Molecular Biology 3 0 2 4
4 BT 2111 Probability & Biostatistics 2 1 2 4
5 HS 2101 Lean Start-up (Fractal) 0 0 3 1
6 HS 2102 Principles of Economics (Fractal) 3 0 0 1.5
7 HS 2103 French-III 0 2 0 0.5
Total Credits 20

Semester IV

S. No Course Code Course Title L T P Total Credits
2 BT 2212 Omic Technologies 3 0 2 4
3 BT 2213 Gene Technology 2 0 4 4
4 BT 2214 Bioprocess Technology 3 0 2 4
5 BT 2215 AI & Data Science for Biotechnologists 3 0 2 4
6 HS 2201 Design Thinking 1 0 2 2
7 HS 2202 Financial Accounting 3 0 0 1.5
8 HS 2203 French- IV 0 2 0 0.5
Total Credits 20

Semester V

S. No Course Code Course Title L T P Total Credits
1 BT 3116 Animal Cell & Tissue Culture Technology 2 0 4 4
2 BT 3117 Bioinformatics & Computational Biology 3 0 2 4
3 BT 3118 Agriculture Biotechnology 3 0 2 4
4 BT 3119 Bioprocess Design & Upscaling 3 0 2 4
5 BT 3020 Elective-I 3 0 0 3
6 BT 3021 Elective-II 3 0 0 3
7 HSS Elective -I 2 0 0 2
Total Credits 24

Semester VI

S. No Course Code Course Title L T P Total Credits
1 BT 3222 Synthetic Biology & Applications 3 0 2 4
2 BT 3223 Food Processing & Nutrition 3 0 2 4
3 BT 3224 Good Manufacturing & Regulatory Practices 1 0 1 1.5
4 BT 3025 Elective-III 3 0 0 3
5 BT 3026 Elective-IV 3 0 0 3
6 HS 3201 Introduction to Professional Development 2 0 0 2
7 HSS Elective HSS Elective II 2 0 0 2
8 PR 301 Project-I (Literature review & seminar) 4 2
Total Credits 21.5

Semester VII

S. No Course Code Course Title L T P Total Credits
1 BT 4227 Green Biotechnology 3 0 0 3
2 BT 4228 Research Methods & IPR 3 0 0 3
4 BT 4027 Elective-V 3 0 0 3
3 BT 4028 Elective-VI 3 0 0 3
5 PR 402 Project-II (Research work and presentation) 0 10 5
6 HSS Elective HSS Elective III 2 0 0 2
Total Credits 19

Semester VIII

S. No Course Code Course Title L T P Total Credits
1 PR 403 Final Year Project-III (Industrial Internship/R&D Institute with major research project) 0 0 24 12
Semester 8
Elective – IV
Elective – V
Year-4 Project
 French  – VIII(Optional)